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Traffic blocked for Highway 42 northbound at I-43 intersection due to tipped tanker truck

TOWN OF SHEBOYGAN, WI (WHBL) -  Traffic is closed to part of the I-43/Highway 42 intersection due to a tipped tanker truck at one of the roundabouts. The incident occurred around 9:45 this morning on the south roundabout, the one closer to Texas Roadhouse and Hardees.  Sheboygan County Sheriff's Sgt. Doug Tuttle said the situation is not hazardous and no major leakage from the tanker is taking place. For now, all traffic on Highway 42 towards Howards Grove at the roundabout is clo...

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FDA staff says Zogenix painkiller has abuse risks

(Reuters) - Drug reviewers said a painkiller developed by Zogenix Inc could possibly be abused more than currently available hydrocodone combination products.

Zogenix's painkiller Zohydro is a single-entity product containing hydrocodone -- a narcotic painkiller. Hydrocodone and oxycodone are often-abused drugs.

Combination hydrocodone drugs usually also contain acetaminophen, the active ingredient in common pain products such as Tylenol.

However, since an overdose of acetaminophen can cause liver damage, especially in patients on other acetaminophen medications, there is a requirement for painkillers without acetaminophen.

The reviewers said the expected higher levels of abuse with Zohydro were based on what has been observed for oxycodone products, according to briefing documents released by the U.S. Food and Drug Administration on Wednesday. (http://link.reuters.com/hux44t)

"The abuse ratio for oxycodone combination products was 24 emergency department visits per million tablets dispensed, compared with 85 visits for oxycodone single-entity ER products," the FDA reviewers said in the documents.

An independent panel of experts will advise the FDA and vote on the drug's safety, efficacy and approval on Friday.

Zogenix shares were down 6 percent at $2.39 in early trade on Wednesday on the Nasdaq.

(Reporting by Esha Dey in Bangalore; Editing by Roshni Menon)

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